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Beloranib hemioxalate

CAS No. 529511-79-3

Beloranib hemioxalate( CKD-732 | ZGN-433 )

Catalog No. M14877 CAS No. 529511-79-3

An analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Beloranib hemioxalate
  • Note
    Research use only, not for human use.
  • Brief Description
    An analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor.
  • Description
    An analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor; strongly inhibit the growth of cancers in xenografted nude model; also causes significant body weight and appetite reduction an anti-obesity agent.Obesity Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CKD-732 | ZGN-433
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Aminopeptidase
  • Recptor
    Aminopeptidase
  • Research Area
    Metabolic Disease
  • Indication
    Obesity

Chemical Information

  • CAS Number
    529511-79-3
  • Formula Weight
    589.682
  • Molecular Formula
    C31H43NO10
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC4=CC=C(C=C4)OCCN(C)C)OC)C.C(=O)(C(=O)O)O
  • Chemical Name
    (3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (E)-3-(4-(2-(dimethylamino)ethoxy)phenyl)acrylate oxalate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kim YM, et al. J Mol Endocrinol. 2007 Apr;38(4):455-65. 2. Morgen M, et al. ACS Chem Biol. 2016 Apr 15;11(4):1001-11. 3. Chun E, et al. Int J Cancer. 2005 Mar 10;114(1):124-30. 4. Hughes TE, et al. Obesity (Silver Spring). 2013 Sep;21(9):1782-8.
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